Effect of methotrexate/dexamethasone combination on epithelial-mesenchymal transition and inflammation gene expression of human RPE cells in-vitro
Our study highlighted the potential pro-apoptotic effect of MTX (at 100 μg/mL) on RPE cells and the synergistic anti-inflammatory impact of MTX/DEXA combination therapy. Nevertheless, this combination did not significantly affect genes associated with EMT. Further research is required to elucidate the clinical implications of these findings in the management of PVR.
Authors
- Fatemeh Sanie‐Jahromi (ORCID: https://orcid.org/0000-0001-9508-2632)
- M. Hossein Nowroozzadeh (ORCID: https://orcid.org/0000-0002-7412-1900)
- Hadi Khani (ORCID: https://orcid.org/0000-0002-4023-5504)
- Mahdi Ravankhah
- Seyed Ahmad Razavizadegan
Institutions
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-30
- DOI
- https://doi.org/10.3389/fphar.2025.1569703
- Citations
- 1
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Shiraz University of Medical Sciences
- Shiraz University