Excess Neprilysin in Placental EVs Impairs CNP-NPRB-Mediated Vasodilation to Trigger Preeclamptic Hypertension
Excessive NEP in placental EVs from preeclamptic pregnancies is transported into the endothelial cells of uterine and placental arteries to cleave and degrade CNP, resulting in compromised CNP paracrine activity and NPRB-mediated cGMP production in adjacent VSMCs and triggering the hypertensive manifestation of preeclampsia.
Authors
- Yuhan Qiu
- Philip N. Baker (ORCID: https://orcid.org/0000-0002-4592-6427)
- Jiayu Huang (ORCID: https://orcid.org/0000-0001-5195-1330)
- Yi Du (ORCID: https://orcid.org/0000-0003-4879-5159)
- Hongbo Qi (ORCID: https://orcid.org/0000-0003-3776-0487)
- Yong Fu (ORCID: https://orcid.org/0000-0001-6480-1147)
- Chao Tong (ORCID: https://orcid.org/0000-0003-0828-2674)
- Mark D. Kilby (ORCID: https://orcid.org/0000-0001-9987-4223)
- Li Lin (ORCID: https://orcid.org/0000-0002-0132-5646)
- Ruixin Chen (ORCID: https://orcid.org/0009-0008-2373-9445)
Institutions
- University of East Anglia (GB)
- Dalian Medical University (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- Children's Hospital of Chongqing Medical University (CN)
- University of Birmingham (GB)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1161/circresaha.124.325673
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 8.23