Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness
Exercise mitigates Ang II-mediated sympathetic nerve interactions with macrophages to activate fibroblasts via inflammation in AA, leading to ECM deposition and aortic stiffness.
Authors
- Tomohiro Yokota (ORCID: https://orcid.org/0000-0003-2540-3810)
- Lili Yang (ORCID: https://orcid.org/0000-0001-6568-0404)
- Enbo Zhu (ORCID: https://orcid.org/0000-0001-8600-8553)
- Ying H. Shen (ORCID: https://orcid.org/0000-0003-4119-115X)
- Seul‐Ki Park (ORCID: https://orcid.org/0000-0001-7027-7679)
- Mark W. Chapleau (ORCID: https://orcid.org/0000-0001-6961-931X)
- Rong Lu (ORCID: https://orcid.org/0000-0002-5151-9246)
- Yan-Ruide Li (ORCID: https://orcid.org/0000-0002-9858-300X)
- Yang K. Xiang (ORCID: https://orcid.org/0000-0003-1786-9143)
- Jae Min Cho (ORCID: https://orcid.org/0000-0002-4461-6945)
- Tzung K. Hsiai (ORCID: https://orcid.org/0000-0003-1734-0792)
- Khoa Vu (ORCID: https://orcid.org/0009-0007-9224-2179)
Institutions
- California Institute of Technology (US)
- University of Iowa (US)
- University of California, Los Angeles (US)
- Baylor College of Medicine (US)
- Broad Center (US)
- Institute of Molecular Biology and Biophysics (RU)
- VA Northern California Health Care System (US)
- VA Greater Los Angeles Healthcare System (US)
- Sylvester Comprehensive Cancer Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1161/circresaha.124.325656
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.11