Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke
Proteogenomic investigation in diverse ancestry populations identified the causal relevance of 10 proteins for IS, with several being potentially novel or repurposed targets that could be prioritized for further investigation.
Authors
- Daniel Avery (ORCID: https://orcid.org/0000-0002-9823-9575)
- Ling Yang (ORCID: https://orcid.org/0000-0001-5750-6588)
- Andri Iona (ORCID: https://orcid.org/0000-0001-8042-9672)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- Dan Schmidt (ORCID: https://orcid.org/0000-0003-0704-8165)
- Kuang Lin (ORCID: https://orcid.org/0000-0002-7360-3385)
- Jinyi Zhou (ORCID: https://orcid.org/0000-0001-6057-862X)
- Alfred Pozarickij (ORCID: https://orcid.org/0000-0002-6937-8496)
- Ximin Hu (ORCID: https://orcid.org/0000-0003-0119-6394)
- Pang Yao (ORCID: https://orcid.org/0000-0002-6875-7435)
- Hannah Fry (ORCID: https://orcid.org/0009-0006-1584-2042)
- Christiana Kartsonaki (ORCID: https://orcid.org/0000-0002-3981-3418)
- Xiao Han (ORCID: https://orcid.org/0000-0002-4557-1304)
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Ka Hung Chan (ORCID: https://orcid.org/0000-0002-3700-502X)
- Xuedong Zhou (ORCID: https://orcid.org/0000-0002-9319-7302)
- Derrick Bennett (ORCID: https://orcid.org/0000-0002-9170-8447)
- Ruth Boxall (ORCID: https://orcid.org/0000-0003-0356-3549)
- Neil Wright (ORCID: https://orcid.org/0000-0002-3946-1870)
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Sushila Burgess (ORCID: https://orcid.org/0000-0003-0356-3549)
- Yaoming Zhai
- Liangcai Ma
- Yiping Chen (ORCID: https://orcid.org/0000-0002-4973-0296)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-7835-9871)
- Tao Wang (ORCID: https://orcid.org/0000-0002-5728-6463)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Yan Lu (ORCID: https://orcid.org/0000-0002-7558-1634)
- Lin Wang (ORCID: https://orcid.org/0000-0002-2571-4320)
- Hao Wang (ORCID: https://orcid.org/0000-0003-2040-4136)
- Hao Wang (ORCID: https://orcid.org/0000-0002-0901-5183)
- Sisi Wang (ORCID: https://orcid.org/0000-0003-2566-4578)
- Chao Liu (ORCID: https://orcid.org/0009-0009-6163-641X)
- James Hou-fu Liu (ORCID: https://orcid.org/0000-0001-9520-5727)
- Yuelong Huang
- Yulian Gao (ORCID: https://orcid.org/0000-0002-3597-5866)
- Wei Gong (ORCID: https://orcid.org/0000-0002-9949-6207)
- Liyuan Zhou (ORCID: https://orcid.org/0000-0001-7485-8163)
- Yujie Hua (ORCID: https://orcid.org/0009-0007-7879-1681)
- Shanpeng Li (ORCID: https://orcid.org/0000-0002-0857-7598)
- Lin Wang (ORCID: https://orcid.org/0000-0002-2610-695X)
- Mingqiang Li (ORCID: https://orcid.org/0000-0001-6308-5062)
- Jianguo Li
- Ruqin Gao (ORCID: https://orcid.org/0000-0002-3845-7829)
- Xiaohui Sun
- Pan He (ORCID: https://orcid.org/0000-0002-6623-3048)
- Xiaolan Ren
- Huimei Li (ORCID: https://orcid.org/0000-0003-2608-0283)
- Ziyan Guo (ORCID: https://orcid.org/0000-0003-1755-941X)
- Xiaocao Tian
- Jinhuai Meng
- Rory Collins
- Richárd Pető
- Jingchao Liu
- Shanpeng Li
- Tian-You He
- Yonglin Zhou
- Qingmei Xia
- Mohsen Mazidi (ORCID: https://orcid.org/0009-0000-9392-4074)
- Shichun Yan
- Qiaohua Xu (ORCID: https://orcid.org/0000-0002-7974-6125)
- Naying Chen
- Kaixu Xie
- Simon Gilbert
- Qinai Xu
- Qijun Gu
- Huarong Sun
- Dongxia Pan (ORCID: https://orcid.org/0000-0001-8104-6892)
- Mingqiang Li (ORCID: https://orcid.org/0000-0002-5178-4138)
- Zhenzhu Tang (ORCID: https://orcid.org/0000-0002-2352-2616)
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Jianrong Jin
- Rong Pan
- Qunhua Nie
- Hao Zhang (ORCID: https://orcid.org/0009-0006-9483-834X)
- Hui Zhang (ORCID: https://orcid.org/0000-0003-1520-2433)
- Licang CDC (ORCID: https://orcid.org/0000-0002-4700-5971)
- Wei Hou (ORCID: https://orcid.org/0000-0001-5600-536X)
- Pei Pei (ORCID: https://orcid.org/0000-0002-5741-6563)
Institutions
- Peking University (CN)
- University of Oxford (GB)
- Nuffield Health (GB)
- Ministry of Education (KR)
- Anna Needs Neuroblastoma Answers (US)
- Ministry of Education and Child Care (CA)
- Medical Research Council (GB)
Publication Details
- Journal
- Stroke
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1161/strokeaha.125.050982
- Citations
- 4
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 5.42