Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke

Proteogenomic investigation in diverse ancestry populations identified the causal relevance of 10 proteins for IS, with several being potentially novel or repurposed targets that could be prioritized for further investigation.

Authors

Institutions

Publication Details

Journal
Stroke
Published
2025-04-30
DOI
https://doi.org/10.1161/strokeaha.125.050982
Citations
4
Primary Topic
Acute Ischemic Stroke Management
Type
article
Field-Weighted Citation Impact
5.42
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke

Daniel Avery, Ling Yang, Andri Iona, Dianjianyi Sun et al.
4 citations
Stroke
Acute Ischemic Stroke Management
5.42
article

Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke

Daniel Avery, Ling Yang, Andri Iona, Dianjianyi Sun, Dan Schmidt, Kuang Lin, Jinyi Zhou, Alfred Pozarickij, Ximin Hu, Pang Yao, Hannah Fry, Christiana Kartsonaki, Xiao Han, Iona Y. Millwood, Ka Hung Chan, Xuedong Zhou, Derrick Bennett, Ruth Boxall, Neil Wright, Huaidong Du, Sushila Burgess, Yaoming Zhai, Liangcai Ma, Yiping Chen, Jun Zhang, Tao Wang, Zhengming Chen, Yan Lu, Lin Wang, Hao Wang, Hao Wang, Sisi Wang, Chao Liu, James Hou-fu Liu, Yuelong Huang, Yulian Gao, Wei Gong, Liyuan Zhou, Yujie Hua, Shanpeng Li, Lin Wang, Mingqiang Li, Jianguo Li, Ruqin Gao, Xiaohui Sun, Pan He, Xiaolan Ren, Huimei Li, Ziyan Guo, Xiaocao Tian, Jinhuai Meng, Rory Collins, Richárd Pető, Jingchao Liu, Shanpeng Li, Tian-You He, Yonglin Zhou, Qingmei Xia, Mohsen Mazidi, Shichun Yan, Qiaohua Xu, Naying Chen, Kaixu Xie, Simon Gilbert, Qinai Xu, Qijun Gu, Huarong Sun, Dongxia Pan, Mingqiang Li, Zhenzhu Tang, Jun Lv, Jianrong Jin, Rong Pan, Qunhua Nie, Hao Zhang, Hui Zhang, Licang CDC, Wei Hou, Pei Pei
article en
4 citations

Abstract

Proteogenomic investigation in diverse ancestry populations identified the causal relevance of 10 proteins for IS, with several being potentially novel or repurposed targets that could be prioritized for further investigation.

StrokeVol. 56(8)
Peking University (CN), University of Oxford (GB), Nuffield Health (GB), Ministry of Education (KR), Anna Needs Neuroblastoma Answers (US), Ministry of Education and Child Care (CA), Medical Research Council (GB)
Good health and well-being
Openalex Percentile: Top 4%
Acute Ischemic Stroke Management
5.42
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.