Tics and Parkinson's Disease: Clinical and Pathophysiological Insights from a Rare Syndromic Association
The evidence drawn from this case series does not support a linear relation between nigrostriatal dopaminergic availability and tics. It suggests that tics may instead arise from a more complex interplay between multiple neurotransmitter systems acting on several networks within the cortico-striatal-thalamic circuits.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Talyta Grippe (ORCID: https://orcid.org/0000-0003-3126-8002)
- Suneil K. Kalia (ORCID: https://orcid.org/0000-0003-2054-1915)
- David A. Isaacs (ORCID: https://orcid.org/0000-0002-9860-1052)
- Alfonso A. Fasano (ORCID: https://orcid.org/0000-0001-5346-0180)
- Irene A. Malaty (ORCID: https://orcid.org/0000-0001-6914-9223)
- Renato P. Munhoz (ORCID: https://orcid.org/0000-0002-4783-4067)
- Tarig Mohammed Abkur (ORCID: https://orcid.org/0000-0003-1486-1875)
- Alexandra Boogers (ORCID: https://orcid.org/0000-0002-5427-0781)
- Lauren A. Hart
- Kailash P. Bhatia (ORCID: https://orcid.org/0000-0001-8185-286X)
- Christos Ganos
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- University of Florida (US)
- Circuit Therapeutics (United States) (US)
- Occupational Cancer Research Centre (CA)
- Krembil Foundation (CA)
- National Hospital for Neurology and Neurosurgery (GB)
- Krembil Research Institute
- University College London (GB)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1002/mdc3.70111
- Citations
- 2
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.61