Highly Enantioselective Formal Synthesis of (+)‐Treprostinil Enabled by Rhodium‐Catalyzed Enyne Cycloisomerization
Comprehensive Summary Herein, a highly enantioselective formal synthesis of (+)‐Treprostinil via the interphenylene prostaglandin E 1 scaffold was described. The chiral multi‐substituted cyclopentanone was constructed via a [Rh(Duanphos)SbF 6 ‐catalyzed asymmetric enyne cycloisomerization and a copper hydride‐mediated conjugate reduction. In addition, a new type of interphenylene prostaglandin scaffold was obtained via a formal Alder‐ene reaction in high yield with excellent chemoselectivity.
Authors
- Gen‐Qiang Chen (ORCID: https://orcid.org/0000-0003-2276-6800)
- Xiaomei Zou
- Xumu Zhang (ORCID: https://orcid.org/0000-0001-5700-0608)
- Yan Zong (ORCID: https://orcid.org/0000-0002-1918-6648)
- Shuang Gao (ORCID: https://orcid.org/0000-0002-6875-9166)
- Qiuchen Huang
Institutions
- Southern University of Science and Technology (CN)
- Ji Hua Laboratory (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Chinese Journal of Chemistry
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1002/cjoc.70043
- Citations
- 3
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China