PSMA PET/CT in biochemical recurrence of prostate cancer with PSA levels ≤ 0.2 ng/mL: a German multicenter analysis of conventional PSMA tracers, including [68Ga]Ga-PSMA-11, [68Ga]Ga-PSMA I&T, and [18F]PSMA-1007
All three radiotracers demonstrated comparable diagnostic performance, with no significant superiority observed between the <sup>68</sup>Ga- and <sup>18</sup>F-labeled tracers in the patient sample investigated (overall pooled detection rate: 29.6%). This positivity rate can serve as an expectation horizon for both the attending physician and the patient in the case of low PSA values. Further studies with larger cohorts, preferably conducted in a prospective setting, are needed to confirm and expand upon our findings.
Authors
- Markus Galler (ORCID: https://orcid.org/0000-0002-5168-9288)
- Caroline Burgard (ORCID: https://orcid.org/0000-0003-1522-8860)
- Lena M. Unterrainer
- Arne Blickle (ORCID: https://orcid.org/0009-0009-2460-7249)
- Philipp E. Hartrampf (ORCID: https://orcid.org/0000-0001-5622-9849)
- Madita Frei
- Julian M.M. Rogasch (ORCID: https://orcid.org/0000-0002-0817-6532)
- Mathias Schreckenberger
- Samer Ezziddin (ORCID: https://orcid.org/0000-0003-4110-3375)
- Manuela A. Hoffmann (ORCID: https://orcid.org/0000-0002-8867-5525)
- Florian Rosar (ORCID: https://orcid.org/0000-0002-2985-4099)
- Hans‐Peter Schmid (ORCID: https://orcid.org/0000-0001-7892-9766)
Institutions
- Johannes Gutenberg University Mainz (DE)
- Humboldt-Universität zu Berlin (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Universitätsklinikum Würzburg (DE)
- Ludwig-Maximilians-Universität München (DE)
- Saarland University (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1007/s00259-025-07292-1
- Citations
- 3
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Universität des Saarlandes