Liquid chromatography-based metallomics and transmission electron microscopy reveal gold nanoparticle surface treatment with vicinal dithiols to abolish protein corona formation
The AuNP-based delivery of immobilized drugs using targeting sequences to cancer tissues can be enhanced by their surface treatment with DMSA or DMPS. Since dithiols left over after the AuNP surface treatment mobilized iron from plasma metalloproteins, excess dithiols must be removed before injecting patients.
Authors
- Negar Pourzadi
- Lorenzo Chiaverini (ORCID: https://orcid.org/0000-0003-4857-9819)
- Inga Ennen
- Jürgen Gailer (ORCID: https://orcid.org/0000-0002-8264-8243)
- Andreas Hütten
- Magdalene Patricia Gieschen
Institutions
- University of Pisa (IT)
- University of Calgary (CA)
- Bielefeld University (DE)
Publication Details
- Journal
- Nanomedicine
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1080/17435889.2025.2495546
- Citations
- 2
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.54
Funders
- University of Calgary