A Comprehensive Assessment and Therapeutic Potential Evaluation of Ethanolic Extract Derived from Origanum vulgare Leaves

The purpose of this study was to investigate the multifaceted bioactive potential of the ethanolic extract obtained from Origanum vulgare leaves. GC-MS analysis has been undertaken to identify the phytoconstituents, which unveiled the intricate profile of components of the extract. In addition, the study further explores the biological activities, including antioxidant, antimicrobial, antidiabetic, anti-inflammatory and cytotoxic assays. The results revealed that the ethanolic leaf extract showed strong antimicrobial action against different human pathogens. Furthermore, a remarkable antioxidant potential was shown by the extract as evidenced by its ability to scavenge free radicals. With respect to antidiabetic properties, the extract demonstrated notable inhibitory effects on key enzymes implicated in glucose metabolism. Anti-inflammatory assay exhibited a significant suppression of inflammatory mediators, suggesting its potential therapeutic applications. Moreover, the cytotoxicity assessments indicated promising results, emphasizing the potential of ethanolic extract of O. vulgare leaves in cancer research. Such evaluation provides valuable insights into the diverse bioactivities of O. vulgare, laying the groundwork for further exploration and utilization of this natural resource in pharmaceutical and therapeutic applications.