Design and Synthesis of Novel 2-Chloro-5-(chloromethyl)pyridine Bioactive Derivatives by Rapid and Efficient Continuous Flow Reaction Module

This study explores the synthesis of new bioactive compounds from the key intermediate 2-chloro-5-(hydrazinylmethyl)pyridine by reacting with various aromatic aldehydes. The process started with 2-chloro-5-(chloromethyl)pyridine, which was used in a flow reactor for a continuous and efficient reaction. The key intermediate, 2-chloro-5-(hydrazinylmethyl)pyridine, was synthesized via a straightforward method and then reacted with aromatic aldehydes under mild conditions to form hydrazone compounds. The compounds were characterized with FTIR, NMR and mass spectroscopic techniques. Preliminary testing showed the promising biological activities, including potential antimicrobial and anti-malarial effects, suggesting their utility in the drug development.