SAT-125 The Prevalence and Etiology of Delayed Puberty in Southern Thailand: A 20-Year Experience

Abstract M. Udomratn: None. S. Jaruratanasirikul: None. T. Saengkaew: None. Delayed puberty (DP) can arise from various etiologies. Distinguishing self-limited DP (SLDP) from congenital hypogonadotropic hypogonadism (CHH) proves challenging due to similar clinical and biochemical markers during adolescent presentation. This study investigated the prevalence of DP in each etiology and associated clinical characteristics, aiming to identify predictive factors differentiating SLDP from CHH. The retrospective study was conducted on 119 patients seeking DP evaluation in a tertiary care hospital between 2002 and 2011. The etiologies were classified based on clinical and biochemical data. The age of 18 years is designated for differentiating between SLDP and CHH. SLDP is the most common cause (44.5%) of DP, more prevalent in boys (52.7% vs 31.1% of total cases). In girls, hypergonadotropic hypogonadism is the most common etiology (40.0% of DP girls, n=18/45), with Turner syndrome as the primary cause (n=11/18). The age of presentation differs significantly among these groups (p=0.006). Permanent HH presented earliest at the age of 11.9 years. CDGP patients typically present at a median age of 13, while functional HH and hyperH present slightly later at 14.5 and 14.3 years, respectively. Height SDS is significantly different among the four etiologies (p=0.004), with functional HH and hypergonadotropic hypogonadism (HHH) groups showing shorter height compared to the other groups. Micropenis and cryptorchidism show a significant difference between the groups (p < 0.001) and were more prevalent in CHH and HHH. Testicular volume, which is bigger in the SDLP group compared to CHH and larger than 3 mL of testicular volume likely to be SLDP 12.46 time to congenital HH (sensitivity 57% specificity 73%) . The presence of micropenis and cryptorchidism is more prevalent in the CHH group, reflecting significant differences (p < 0.001 and p = 0.006, respectively). Bone age is also significantly lower in the SDLP group. In summary, the primary cause of DP was SLDP in boys and hypergonadotropic hypogonadism in girls. Boys with micropenis, small testes and low weight SDS were more likely to be CHH than SLDP. Saturday, June 1, 2024