Cardiovascular outcomes in adults with low-density lipoprotein cholesterol levels of ≥4.9 mmol/L: 15-year follow-up of the CoLaus|PsyCoLaus study
The study reports an association between LDL-C ≥4.9 mmol/L and ASCVD in a large cohort from Switzerland. However, we found heterogeneity in risk across different subgroups. Furthermore, polygenic risk for coronary artery disease seems to partly account for this association. While further studies are needed to assess the cardiovascular risk specifically in healthier subgroups, our results suggest, that a more precise risk assessment is needed for individuals with LDL-C ≥4.9 mmol/L.
Authors
- Roxane de La Harpe (ORCID: https://orcid.org/0000-0002-2885-3799)
- Drahomir Aujesky (ORCID: https://orcid.org/0000-0002-3970-2670)
- Nicolas Rodondi (ORCID: https://orcid.org/0000-0001-9083-6896)
- Julien Vaucher (ORCID: https://orcid.org/0000-0002-3230-3693)
- J Teuscher
- Pedro Marques‐Vidal (ORCID: https://orcid.org/0000-0002-4548-8500)
- Stéphanie Baggio (ORCID: https://orcid.org/0000-0002-5347-5937)
- Lucy Bolt (ORCID: https://orcid.org/0009-0008-1642-9801)
- Elisavet Moutzouri (ORCID: https://orcid.org/0000-0002-7713-7553)
Institutions
- University of Bern (CH)
- University of Fribourg (CH)
- University Hospital of Bern (CH)
- Primary Health Care (QA)
- University of Lausanne (CH)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1093/eurjpc/zwaf268
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Science Foundation
- GlaxoSmithKline
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Akademie der Medizinischen Wissenschaften
- Chinese Society of Clinical Oncology