Diagnostic insights into solid pseudopapillary neoplasms of the pancreas: a decade of experience with pediatric representation
SPNs present with distinctive immunohistochemical signatures that are critical for accurate diagnosis, particularly in morphologically ambiguous or pediatric cases. CD99 and LEF1 are highly sensitive markers that, in combination with β-catenin and Cyclin D1, enhance diagnostic precision. These findings emphasize the central role of Wnt/β-catenin signaling in SPN pathogenesis and underscore the importance of integrating clinicopathological and molecular data for comprehensive tumor assessment.
Authors
- R. Salama (ORCID: https://orcid.org/0000-0002-1102-9306)
- Maha Othman (ORCID: https://orcid.org/0000-0001-7562-203X)
- Neveen Tahoun (ORCID: https://orcid.org/0000-0002-0562-0335)
- Noura A. A. Ebrahim (ORCID: https://orcid.org/0009-0001-7037-680X)
- Dalia Abdelfatah (ORCID: https://orcid.org/0000-0002-8598-7128)
Institutions
- Cairo University (EG)
- National Water Research Center (EG)
- Children Cancer Hospital (EG)
- Ras al-Khaimah Medical and Health Sciences University (AE)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s13000-025-01648-9
- Citations
- 8
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- Cairo University
- Science and Technology Development Fund
- National Cancer Institute, Cairo University
- National Cancer Institute