The <scp>NLRP3</scp> inhibitor <scp>NT</scp>‐0796 enhances and sustains <scp>GLP</scp>‐<scp>1R</scp> agonist‐mediated weight loss in a murine diet‐induced obesity model
Alleviation of obesity-associated inflammation via NLRP3 inhibition 1) constitutes an effective weight-loss strategy as monotherapy in mice with DIO, 2) augments the weight-loss efficacy of a subtherapeutic dose of semaglutide, and 3) blocks recovery of lost weight following cessation of semaglutide.
Authors
- John R. Doedens (ORCID: https://orcid.org/0000-0001-9551-0019)
- Valérie Reader (ORCID: https://orcid.org/0000-0003-1969-2425)
- Nicola Lindsay
- Zsofia Digby
- Peter Thornton (ORCID: https://orcid.org/0000-0002-2489-3507)
- Nicholas Clarke
- Alan P. Watt
Publication Details
- Journal
- Obesity
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1002/oby.24305
- Citations
- 4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- University of Washington