<i>LINC00323</i> variant is associated with increased risk of essential tremor
Essential tremor (ET) is a common adult movement disorder, with accumulating evidence suggesting that genetic factors primarily account for ET risk. However, replication studies on the genetic variants have yielded inconsistent results. In our case-control study, we show that the LINC00323 variant, identified in a European GWAS study, is associated with an increased risk of ET in our Asian cohort. Our results corroborate the association of this risk variant with ET shared by diverse ethnicities. Functional studies of this variant have the potential to identify novel therapeutic targets for the general ET population.
Authors
- Bin Xiao (ORCID: https://orcid.org/0000-0003-2986-4980)
- Ebonne Ng
- Ling Ling Chan (ORCID: https://orcid.org/0000-0001-7603-7334)
- Aaron Shengting (ORCID: https://orcid.org/0000-0002-7644-5538)
- Brendan Jen‐Wei Tan
- Thomas Welton (ORCID: https://orcid.org/0000-0002-9503-2093)
- Qiao Yang Sun (ORCID: https://orcid.org/0000-0002-7842-7034)
- Louis C.S. Tan (ORCID: https://orcid.org/0000-0002-8415-401X)
- Eng‐King Tan (ORCID: https://orcid.org/0000-0002-8807-1529)
- Wing Lok Au
- Kay Yaw Tay
- Kumar Manharlal Prakash (ORCID: https://orcid.org/0000-0002-4853-5026)
Institutions
- Duke-NUS Medical School (SG)
- National Neuroscience Institute (SG)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1002/acn3.52303
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- National Medical Research Council