The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells
These data suggest that targeting extracellular matrix (ECM) stiffness may hinder the progress of CC. Notably, targeting Piezo1 may offer promising clinical value for CC therapy.
Authors
- Lanyue Zhang (ORCID: https://orcid.org/0000-0002-5153-5473)
- Yang Li (ORCID: https://orcid.org/0000-0002-2008-2045)
- Tingting Liu (ORCID: https://orcid.org/0000-0001-9623-7114)
- Hua Liang
- Fujin Shen
- Juexiao Deng
- Wenxin Liao
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1007/s12672-025-02456-9
- Citations
- 5
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Fundamental Research Funds for the Central Universities