Distinct gut microbiome characteristics and dynamics in patients with Parkinson’s disease based on the presence of premotor rapid-eye movement sleep behavior disorders
We determined that the gut microbiome dynamics in patients with PD according to the disease progression depend on the presence of premotor RBD. Notably, early-stage PD-RBD(+) demonstrated distinct gut microbial characteristics, potentially contributing to exacerbation of PD pathophysiology. This outcome may contribute to the development of new therapeutic strategies targeting the gut microbiome in PD. Video Abstract.
Authors
- Sun Ju Chung (ORCID: https://orcid.org/0000-0003-4118-8233)
- Myeong Geun Choi (ORCID: https://orcid.org/0000-0003-3538-1993)
- Jin‐Woo Bae (ORCID: https://orcid.org/0000-0001-6433-5270)
- Jae‐Yun Lee (ORCID: https://orcid.org/0000-0001-7973-8128)
- Sungyang Jo (ORCID: https://orcid.org/0000-0001-5097-2340)
- Ji‐Hyun Lee (ORCID: https://orcid.org/0000-0001-6420-5150)
- Sang-Jin Lee
- Ki-jeong Kim (ORCID: https://orcid.org/0000-0003-1958-1282)
- Hyun Sik Kim (ORCID: https://orcid.org/0000-0002-4672-7710)
Institutions
- Ulsan College (KR)
- Asan Medical Center (KR)
- Kyung Hee University (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- Microbiome
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s40168-025-02095-w
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea