Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer
Our study demonstrates that BRD4 epigenetically regulates the <i>H19</i>-mediated transcriptional control of adhesion molecules involved in collective migration and metastatic dissemination. Importantly, these effects are independent of AR status, suggesting that targeting the <i>H19</i>/BRD4 axis may represent a promising therapeutic avenue for advanced PCa.
Authors
- Antonella Farsetti (ORCID: https://orcid.org/0000-0002-8603-7925)
- Simona Nanni (ORCID: https://orcid.org/0000-0002-3320-1584)
- Dante Rotili (ORCID: https://orcid.org/0000-0002-8428-8763)
- Claudio Grassi (ORCID: https://orcid.org/0000-0001-7253-1685)
- Luca Cis
- Cristian Ripoli (ORCID: https://orcid.org/0000-0002-5315-0163)
- Sara De Martino (ORCID: https://orcid.org/0000-0002-6226-4090)
- Carlo Gaetano (ORCID: https://orcid.org/0000-0002-5238-1832)
- Aurora Aiello (ORCID: https://orcid.org/0000-0002-8303-1528)
- Francesco Pinto (ORCID: https://orcid.org/0000-0003-1937-9957)
- Valeria Pecci (ORCID: https://orcid.org/0000-0001-9170-3593)
- Francesco Pierconti (ORCID: https://orcid.org/0000-0003-0951-4131)
- M Borsa (ORCID: https://orcid.org/0009-0005-8722-4350)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Non-Coding RNA
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3390/ncrna11030033
- Citations
- 2
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Ministero della Salute
- Università Cattolica del Sacro Cuore
- Fondazione Italiana per la Ricerca sul Cancro