Physical activity changes during midlife link to brain integrity and amyloid burden
Boosting physical activity in midlife may have beneficial effects in preclinical AD. Physical activity increases relate to lower Aβ burden in a dose-dependent manner. Remaining sedentary links to lower cortical thickness in AD-vulnerable structures. New adherence to WHO-recommended physical activity levels may enhance brain health.
Authors
- Müge Akinci (ORCID: https://orcid.org/0000-0002-0845-933X)
- Karine Fauria (ORCID: https://orcid.org/0000-0003-1506-4405)
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Eleni Palpatzis (ORCID: https://orcid.org/0000-0001-8478-273X)
- Eider M. Arenaza‐Urquijo (ORCID: https://orcid.org/0000-0001-7016-7576)
- Judith García‐Aymerich (ORCID: https://orcid.org/0000-0002-7097-4586)
- Mahnaz Shekari (ORCID: https://orcid.org/0000-0003-1336-6768)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Marina García‐Prat
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Carme Deulofeu
- Pablo Aguilar‐Domínguez
Institutions
- Universitat Pompeu Fabra (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Barcelona Institute for Global Health (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Hospital del Mar Research Institute (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1002/alz.70007
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Association
- “la Caixa” Foundation
- EU Joint Programme – Neurodegenerative Disease Research
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- European Social Fund