Smoking and asthma mediate the protective effect of educational attainment on chronic obstructive pulmonary disease risk: a mediation Mendelian randomization analysis
These findings provide support for the causal impact of educational attainment on the occurrence of COPD, with a significant portion of this causal effect being mediated through modifiable risk factors. On the premise of controlling socioeconomic - status - related confounders, an increase in educational attainment may provide multi-level intervention targets for COPD prevention through intervenable pathways such as improving health behaviors and environmental exposure.
Authors
- Yue Zheng (ORCID: https://orcid.org/0000-0002-0117-9183)
- Fenghai Ren
- Sainan Pang
- Ying Zhao (ORCID: https://orcid.org/0000-0001-5079-9672)
- Huiyan Li (ORCID: https://orcid.org/0000-0002-5769-1020)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-1475-2276)
- Yanbo Wang (ORCID: https://orcid.org/0000-0001-7329-4386)
- Bai Xue (ORCID: https://orcid.org/0000-0001-8008-8425)
- Lantao Chen (ORCID: https://orcid.org/0009-0009-9179-5876)
- Erliang Guo
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- BMC Pulmonary Medicine
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s12890-025-03658-1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00