Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity
Our novel characterisation of platelets in type 1 diabetes shows a maladaptive phenotype with increased basal activity together with hyperactivation following stimulation and diminished responses to inhibition. Insulin resistance appears to further drive this adverse thrombotic phenotype, suggesting an enhanced platelet-driven cardiovascular risk in those with type 1 diabetes and reduced insulin sensitivity.
Authors
- Beth A. Webb (ORCID: https://orcid.org/0000-0001-9075-8250)
- Daisie M Yates (ORCID: https://orcid.org/0000-0001-7566-1653)
- Rebecca Sagar (ORCID: https://orcid.org/0000-0001-7972-3321)
- Sam Pearson (ORCID: https://orcid.org/0000-0002-4943-6759)
- Noppadol Kietsiriroje (ORCID: https://orcid.org/0000-0002-5076-4450)
- Khalid M. Naseem (ORCID: https://orcid.org/0000-0002-3870-8747)
- Ramzi Ajjan (ORCID: https://orcid.org/0000-0002-1636-3725)
- Matthew S. Hindle (ORCID: https://orcid.org/0000-0002-5633-2034)
- Lih T. Cheah (ORCID: https://orcid.org/0000-0002-2805-9931)
Institutions
- University of Leeds (GB)
- Prince of Songkla University (TH)
- Leeds Teaching Hospitals NHS Trust (GB)
- Leeds Beckett University (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1007/s00125-025-06429-z
- Citations
- 5
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 6.47
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- University of Leeds
- Leeds Biomedical Research Centre