Development and analysis of a remimazolam pharmacokinetics and pharmacodynamics model with proposed dosing and concentrations for anaesthesia and sedation
A PK-PD model for remimazolam was developed for a broad, diverse population. Dosing and target concentrations are proposed that are clinically useful for anaesthesia and sedation, especially for target-controlled infusion administration.
Authors
- Douglas J. Eleveld (ORCID: https://orcid.org/0000-0002-0340-3847)
- Pieter Colin (ORCID: https://orcid.org/0000-0003-3616-5539)
- Jeroen V. Koomen (ORCID: https://orcid.org/0000-0001-7253-3998)
- Michel Struys (ORCID: https://orcid.org/0000-0003-0421-536X)
- Thomas Stoehr (ORCID: https://orcid.org/0000-0001-7162-5786)
- Johannes P. van den Berg (ORCID: https://orcid.org/0000-0001-5624-714X)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Paion (Germany) (DE)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1016/j.bja.2025.02.038
- Citations
- 10
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 21.91
Funders
- Rijksuniversiteit Groningen
- Universitair Medisch Centrum Groningen