Microwave-assisted synthesis of pyrazoles - a mini-review

Heterocyclic compounds including pyrazole have a serious area in the field of medicinal chemistry and modern drug development studies. Pyrazole is a five-membered ring system containing two adjacent nitrogen atoms. Pyrazole attracts great attention due to its wide biological activity scale and potential in the development of new drug molecules. Traditional methods have been used in the general synthesis methods of pyrazole for a long time, but since these methods can be performed within certain limits, it is necessary to benefit from new and sustainable methodologies. In this review, the use and benefits of microwave (MW)-assisted techniques under the general title of green chemistry will be emphasized. The use of MW techniques stands out with its advantages such as increasing the efficiency of synthesis, obtaining selective products and preventing environmental pollution. The area of use of the MW method in pyrazole synthesis, synthesis mechanisms, organic synthesis methods and benefits are examined in this study. The MW method used in the synthesis of the pyrazole ring, which stands out with its bioactive diversity, will be encountered much more in the coming years.