GALANTAMINE AS ACETYL CHOLINESTERASE INHIBITOR FOR TREATMENT OF ALZHEIMER’S DISEASE: AN ARTIFICIAL INTELLIGENCE APPROACH

Artificial intelligence (AI) is an emerging field and it has been disseminated in all areas of research. Its importance in medical sciences is also very crucial. The aim of this study was to evaluate the efficacy of Galantamine for Alzheimer’s disease as acetyl cholinesterase inhibitor. Protein for study was retrieved through protein databank (PDB ID - 1B41) and ligand was removed using Discovery Studio. Analogs for docking were chosen from zinc database and docking was performed using Auto dock tool and auto dock vine, after docking ADMET properties were calculated against the possible inhibitors using MedChem designer. Drug scoring was done using DSX Online forum. ZINC39293199 has good affinity as compared to other analogs of galantamine.