Comparison of plasma sterilizer and conventional laminar flow room in allogeneic hematopoietic stem cell transplant recipients

Patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) are typically placed in a laminar air flow room until hematopoietic reconstitution occurs. In this study, we compared the differences in clinical outcomes between patients receiving allo-HSCT in a conventional laminar flow room (<i>n</i> = 200) and those receiving allo-HSCT in a plasma sterilizer environment (<i>n</i> = 201). The overall infection rates (20.4% vs 25.5%, <i>P</i> = 0.224) and the sites of infection (sepsis, perianal infection, and catheter-related infection) were comparable between the two groups. Additionally, the engraftment times were comparable between the two groups in terms of time to allo-HSCT, leukocyte engraftment time, and platelet engraftment time. The 100-day posttransplantation clinical outcomes were also comparable between the two groups in terms of the probability of overall survival (98.5% vs 99.5%, <i>P</i> = 0.316), leukemia-free survival (96.5% vs 96.5%, <i>P</i> = 0.991), the cumulative incidence of relapse (2.0% vs 3.0%, <i>P</i> = 0.523), non-relapse mortality (1.5% vs 0.5%, <i>P</i> = 0.316) and acute graft-versus-host disease (23.4% vs 22.0%, <i>P</i> = 0.723). Thus, our results demonstrated that receiving allo-HSCT via a plasma sterilizer did not increase the risk of pre-engraftment infection, and the clinical outcomes of these patients were comparable to those of patients in a conventional laminar flow room.

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Publication Details

Journal
Cell Transplantation
Published
2025-04-30
DOI
https://doi.org/10.1177/09636897251335722
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
Field-Weighted Citation Impact
0.00

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article

Comparison of plasma sterilizer and conventional laminar flow room in allogeneic hematopoietic stem cell transplant recipients

Jingyu Gao, Dao-Xing Deng, Xiaohui Zhang, Shanshan Hu et al.
Cell Transplantation
Hematopoietic Stem Cell Transplantation
article

Comparison of plasma sterilizer and conventional laminar flow room in allogeneic hematopoietic stem cell transplant recipients

Jingyu Gao, Dao-Xing Deng, Xiaohui Zhang, Shanshan Hu, Ling Ma, Wen‐Xuan Huo, Yuqing Xia, Xiao‐Dong Mo, Wenwen Xiao, Boning Liu, Yi‐Jie Jia, Jiating Wang, D. Yao, Yuanyuan Zhang, Jing Liu, Junxia Wang, Wei Hu, Xiao‐Jun Huang, Ce Shi, Yegang Ma, Hao Yin, Xiaoshuang Han, Qianheng Du, Jun Kong, Yi Xia, Dong Hun Han, Fengmei Zheng, Leqing Cao, Ting Wang
article en

Abstract

Patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) are typically placed in a laminar air flow room until hematopoietic reconstitution occurs. In this study, we compared the differences in clinical outcomes between patients receiving allo-HSCT in a conventional laminar flow room (<i>n</i> = 200) and those receiving allo-HSCT in a plasma sterilizer environment (<i>n</i> = 201). The overall infection rates (20.4% vs 25.5%, <i>P</i> = 0.224) and the sites of infection (sepsis, perianal infection, and catheter-related infection) were comparable between the two groups. Additionally, the engraftment times were comparable between the two groups in terms of time to allo-HSCT, leukocyte engraftment time, and platelet engraftment time. The 100-day posttransplantation clinical outcomes were also comparable between the two groups in terms of the probability of overall survival (98.5% vs 99.5%, <i>P</i> = 0.316), leukemia-free survival (96.5% vs 96.5%, <i>P</i> = 0.991), the cumulative incidence of relapse (2.0% vs 3.0%, <i>P</i> = 0.523), non-relapse mortality (1.5% vs 0.5%, <i>P</i> = 0.316) and acute graft-versus-host disease (23.4% vs 22.0%, <i>P</i> = 0.723). Thus, our results demonstrated that receiving allo-HSCT via a plasma sterilizer did not increase the risk of pre-engraftment infection, and the clinical outcomes of these patients were comparable to those of patients in a conventional laminar flow room.

Cell TransplantationVol. 34
Peking University (CN), Peking University People's Hospital (CN)
Beijing Municipal Natural Science Foundation, National Key Research and Development Program of China
Openalex Percentile: Top 88%
Hematopoietic Stem Cell Transplantation
DOIOpen Access PDFOpenAlex
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