Longitudinal surveillance of the molecular evolution of methicillin-resistant <i>Staphylococcus aureus</i> isolates from pediatric patients in Shanghai, China, from 2013 to 2022
Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) has emerged as a significant global health concern. Previous research on MRSA epidemiology has predominantly focused on adult populations or targeted specific infection sites, while there was limited research on the long-term evolution of MRSA from the pediatric population. This study addresses this knowledge gap by conducting a comprehensive, 10-year surveillance of pediatric MRSA isolates using whole-genome sequencing. We characterized the molecular typing, as well as the phenotypic and genotypic antimicrobial resistance profiles, and virulence factors present in MRSA isolates obtained from children. Our results highlight the imperative for continuous, vigilant monitoring of MRSA within the pediatric demographic to track its evolving genetic landscape.
Authors
- Huihong Qin
- Hong Zhang (ORCID: https://orcid.org/0000-0002-0886-9531)
- Chun Wang
- Tiandong Zhang (ORCID: https://orcid.org/0000-0002-7124-9570)
- Fangyou Yu (ORCID: https://orcid.org/0000-0003-4924-2484)
- Zhan Ma (ORCID: https://orcid.org/0000-0003-3686-4057)
- Liang Chen (ORCID: https://orcid.org/0000-0001-5845-2235)
- Wenxin Liu (ORCID: https://orcid.org/0000-0002-5733-1244)
- Jiao Zhang (ORCID: https://orcid.org/0000-0001-9920-107X)
- Fangyuan Yu (ORCID: https://orcid.org/0009-0004-6973-3955)
- Fen Pan
- Wenhao Weng (ORCID: https://orcid.org/0000-0002-3185-6421)
- Qianyue Wu
- X. Pan (ORCID: https://orcid.org/0000-0003-1034-6008)
- Bingjie Wang (ORCID: https://orcid.org/0009-0003-8361-5843)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Pulmonary Hospital (CN)
- Shanghai Children's Hospital (CN)
- Institute of Infection and Immunity (CA)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- mSystems
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1128/msystems.00371-25
- Citations
- 4
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 5.58