Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival

Hypomagnesemia at the time of CAR-T infusion is associated with an unfavorable inflammatory profile and decreased response and survival in LBCL patients receiving axi-cel. These findings suggest a potentially actionable prognostic factor for patients with large cell lymphoma undergoing CAR-T.

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Publication Details

Journal
Experimental Hematology and Oncology
Published
2025-04-30
DOI
https://doi.org/10.1186/s40164-025-00623-w
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00

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article

Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival

Abdullah S. Al Saleh, Gordon Ruan, Kodi Martinez, Jonas Paludo et al.
Experimental Hematology and Oncology
CAR-T cell therapy research
article

Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival

Abdullah S. Al Saleh, Gordon Ruan, Kodi Martinez, Jonas Paludo, Januario E. Castro, Panwen Wang, Yi Lin, Mohamed A. Kharfan‐Dabaja, Sangeetha Gandhi, Hemant S. Murthy, Mike Mattie, Gabrielle McCoy, Urshila Durani, Elham Babadi, José C. Villasboas, Paul Joseph Hampel, Patrizia Mondello, Henan Zhang, Allison Rosenthal, Saad S. Kenderian, Matthew Hathcock, Jennifer Gile, Jenny Kim, N. Nora Bennani, Patrick B. Johnston, Arushi Khurana, Rhine R. Shen, Kevin M. Regan, Eider Moreno, Radhika Bansal, Javier Muñoz, Ying Li, Junwen Wang, Zixing Wang, Yucai Wang, Thomas E. Witzig, Zuoyi Shao, Stephen M. Ansell
article en

Abstract

Hypomagnesemia at the time of CAR-T infusion is associated with an unfavorable inflammatory profile and decreased response and survival in LBCL patients receiving axi-cel. These findings suggest a potentially actionable prognostic factor for patients with large cell lymphoma undergoing CAR-T.

Experimental Hematology and OncologyVol. 14(1)
Mayo Clinic (US), Mayo Clinic in Arizona (US), Gilead Sciences (Australia) (AU), Mayo Clinic in Florida (US)
National Institutes of Health, Center for Individualized Medicine, Mayo Clinic, National Cancer Institute
Openalex Percentile: Top 86%
CAR-T cell therapy research
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