Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival
Hypomagnesemia at the time of CAR-T infusion is associated with an unfavorable inflammatory profile and decreased response and survival in LBCL patients receiving axi-cel. These findings suggest a potentially actionable prognostic factor for patients with large cell lymphoma undergoing CAR-T.
Authors
- Abdullah S. Al Saleh (ORCID: https://orcid.org/0000-0003-1111-556X)
- Gordon Ruan
- Kodi Martinez
- Jonas Paludo (ORCID: https://orcid.org/0000-0002-7350-5531)
- Januario E. Castro (ORCID: https://orcid.org/0000-0003-2785-0892)
- Panwen Wang (ORCID: https://orcid.org/0000-0002-4614-8970)
- Yi Lin (ORCID: https://orcid.org/0000-0003-0282-2414)
- Mohamed A. Kharfan‐Dabaja (ORCID: https://orcid.org/0000-0001-7394-5185)
- Sangeetha Gandhi
- Hemant S. Murthy (ORCID: https://orcid.org/0000-0003-4534-4248)
- Mike Mattie (ORCID: https://orcid.org/0000-0003-0868-3865)
- Gabrielle McCoy
- Urshila Durani (ORCID: https://orcid.org/0000-0003-1860-2424)
- Elham Babadi
- José C. Villasboas (ORCID: https://orcid.org/0000-0002-2907-0809)
- Paul Joseph Hampel (ORCID: https://orcid.org/0000-0003-1292-3024)
- Patrizia Mondello (ORCID: https://orcid.org/0000-0002-0355-3757)
- Henan Zhang (ORCID: https://orcid.org/0000-0002-5680-4687)
- Allison Rosenthal (ORCID: https://orcid.org/0000-0002-8915-3163)
- Saad S. Kenderian (ORCID: https://orcid.org/0000-0003-2767-3830)
- Matthew Hathcock (ORCID: https://orcid.org/0000-0003-3447-6595)
- Jennifer Gile (ORCID: https://orcid.org/0000-0001-6972-7986)
- Jenny Kim (ORCID: https://orcid.org/0009-0008-6816-1499)
- N. Nora Bennani (ORCID: https://orcid.org/0000-0001-8358-5953)
- Patrick B. Johnston
- Arushi Khurana (ORCID: https://orcid.org/0000-0001-5645-0949)
- Rhine R. Shen (ORCID: https://orcid.org/0009-0000-8883-0727)
- Kevin M. Regan
- Eider Moreno
- Radhika Bansal (ORCID: https://orcid.org/0000-0003-0964-098X)
- Javier Muñoz (ORCID: https://orcid.org/0000-0002-9060-8911)
- Ying Li (ORCID: https://orcid.org/0000-0002-0882-5926)
- Junwen Wang (ORCID: https://orcid.org/0000-0003-2426-8944)
- Zixing Wang (ORCID: https://orcid.org/0000-0002-9617-2493)
- Yucai Wang (ORCID: https://orcid.org/0000-0002-1576-8341)
- Thomas E. Witzig
- Zuoyi Shao (ORCID: https://orcid.org/0009-0002-3519-6800)
- Stephen M. Ansell
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Gilead Sciences (Australia) (AU)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s40164-025-00623-w
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Center for Individualized Medicine, Mayo Clinic
- National Cancer Institute