Transition-Metal Free Photocatalytic Synthesis of Acylsulfonamides
We have developed a transition-metal-free photocatalytic S-N coupling reaction utilizing sodium organosulfinate and hydroxamic acid to synthesize acylsulfonamides. Employing 2,3,5,6-tetra(9H-carbazol-9-yl)benzonitrile (4CzBN) as a photocatalyst, this method enables the preparation of a wide range of acylsulfonamides from arylhydroxamic acids or <i>N</i>-hydroxycarbamates. Mechanistic studies indicate that the generation of singlet oxygen (<sup>1</sup>O<sub>2</sub>) via the Energy Transfer Process (EnT) is crucial for facilitating the reaction. This approach offers a sustainable and efficient pathway for acylsulfonamide synthesis under mild conditions.
Authors
- Cong Ma (ORCID: https://orcid.org/0000-0001-9245-0356)
- Long Yin Lam (ORCID: https://orcid.org/0000-0001-5503-0061)
Institutions
- Hong Kong Polytechnic University (HK)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c01129
- Citations
- 5
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Research Grants Council, University Grants Committee
- Hong Kong Polytechnic University