Effect of very preterm delivery on outcomes following in utero spina bifida repair
Very preterm birth following in utero spina bifida repair results in significant perinatal mortality and neonatal morbidity. Delivery prior to 30 weeks of gestation occurs in 9% of patients after in utero spina bifida repair, resulting in a 21% perinatal mortality rate. However, even among those who delivered very preterm, a reduction in VP shunt rates, a benefit of in utero repair, appears to be preserved. Further data are warranted to assess the impact of prematurity following in-utero surgery on ambulation and developmental outcomes.
Authors
- Joseph B. Lillegard (ORCID: https://orcid.org/0000-0002-1972-5074)
- Jena L. Miller (ORCID: https://orcid.org/0000-0003-0189-8265)
- Ueli Moehrlen (ORCID: https://orcid.org/0000-0001-6418-1136)
- Virginia Lijewski (ORCID: https://orcid.org/0000-0002-1775-0030)
- Tim Van Mieghem (ORCID: https://orcid.org/0000-0002-3034-6905)
- Stephen P. Emery (ORCID: https://orcid.org/0000-0002-8539-7566)
- Samer K. Elbabaa (ORCID: https://orcid.org/0000-0003-1733-1941)
- Yair J. Blumenfeld (ORCID: https://orcid.org/0000-0002-9440-8175)
- Foong‐Yen Lim (ORCID: https://orcid.org/0000-0003-4362-8431)
- Aimen F. Shaaban (ORCID: https://orcid.org/0000-0002-9459-107X)
- Mauro Schenone (ORCID: https://orcid.org/0000-0002-2118-4852)
- Michael V. Zaretsky (ORCID: https://orcid.org/0000-0001-6465-8846)
- KuoJen Tsao (ORCID: https://orcid.org/0000-0002-1223-6980)
- Anita J. Moon‐Grady (ORCID: https://orcid.org/0000-0003-3822-693X)
- Caitlin Clifford
- François I. Luks (ORCID: https://orcid.org/0000-0002-4208-8691)
- William Goodnight (ORCID: https://orcid.org/0000-0001-8813-6743)
- Daniel Skupski
- Amy J. Wagner
- Christina Buchanan (ORCID: https://orcid.org/0000-0001-6541-0498)
- Timothy M. Crombleholme
- Julie S. Moldenhauer
- Jagruti Anadkat (ORCID: https://orcid.org/0000-0001-8279-9933)
- Hanmin Lee (ORCID: https://orcid.org/0000-0002-7847-4893)
- Kelly Bennett
Institutions
- University of North Carolina at Chapel Hill (US)
- Children's Hospital of Wisconsin (US)
- Cincinnati Children's Hospital Medical Center (US)
- Mount Sinai Hospital (CA)
- Lurie Children's Hospital (US)
- Lucile Packard Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- University of Connecticut (US)
- Concern Worldwide US (US)
- Johns Hopkins University (US)
- Orlando Health (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Vanderbilt University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Arnold Palmer Hospital for Children (US)
- Connecticut Children's Medical Center (US)
- Magee-Womens Hospital (US)
- Hasbro Children's Hospital (US)
- University Children's Hospital Zurich (CH)
- Children's Minnesota (US)
- University of Pittsburgh Medical Center (US)
- Mayo Clinic in Florida (US)
- Children's Center (US)
- Saint Louis University (US)
- The University of Texas Health Science Center at Houston (US)
- Stanford University (US)
Publication Details
- Journal
- Pregnancy
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1002/pmf2.70027
- Citations
- 2
- Primary Topic
- Spinal Dysraphism and Malformations
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- National Institutes of Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development