Labelling patients as allergic to beta-lactam antibiotics is associated with periprosthetic joint infection up to five years following knee arthroplasty
In this longitudinal study, patients labelled as having a BL allergy were associated with having increased risk of PJI following TKA, particularly within the first five years. Given the high rate of patients being mislabelled, we recommend that patients labelled as having a BL allergy should be prioritized for formal allergy assessment and evaluation. Further studies on the impact of preoperative antibiotic allergy delabelling initiatives should be encouraged.
Authors
- Valerie Chiang (ORCID: https://orcid.org/0000-0001-9250-967X)
- Philip Hei Li (ORCID: https://orcid.org/0000-0002-9155-9162)
- Pky Chiu (ORCID: https://orcid.org/0000-0001-9284-5817)
- Henry Fu (ORCID: https://orcid.org/0000-0001-7520-6845)
- Hugo W. F. Mak (ORCID: https://orcid.org/0000-0001-5085-0837)
- Michelle Hilda Luk (ORCID: https://orcid.org/0000-0001-6859-9011)
- Amy Cheung (ORCID: https://orcid.org/0000-0002-4992-6176)
- Man Hong Cheung (ORCID: https://orcid.org/0000-0001-6617-8088)
Institutions
- Queen Mary Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- The Bone & Joint Journal
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1302/0301-620x.107b5.bjj-2024-1007.r1
- Citations
- 4
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 5.58