Clinical effectiveness of an individually tailored strengthening programme, including progressive resistance exercises and advice, compared to usual care for ambulant adolescents with spastic cerebral palsy (ROBUST trial): a parallel group randomized
The primary outcome is functional mobility measured using the child-/parent-reported Gait Outcomes Assessment List (GOAL) at six months. Secondary outcomes are: clinician-assessed muscle strength (Five Times Sit-to-Stand Test) and motor function (timed up and go test) at six months; functional mobility (GOAL) at 12 months; independence (GOAL subdomain A), balance (GOAL subdomain A, B, D), pain and discomfort (GOAL subdomain C), health-related quality of life (youth version of the EuroQol five-dimension questionnaire; EQ-5D-Y), educational attendance, exercise adherence, and additional physiotherapy treatment (six and 12 months). The primary analysis will be intention to treat.
Authors
- Heidi Fletcher (ORCID: https://orcid.org/0000-0002-6518-6024)
- Jennifer Ryan (ORCID: https://orcid.org/0000-0003-3768-2132)
- Jeremy Parr (ORCID: https://orcid.org/0000-0002-2507-7878)
- Helen E. Wood (ORCID: https://orcid.org/0009-0008-6940-6427)
- Tim Theologis (ORCID: https://orcid.org/0000-0002-4758-9081)
- Gregory B. Firth (ORCID: https://orcid.org/0000-0002-1594-2290)
- Sally Hopewell (ORCID: https://orcid.org/0000-0002-6881-6984)
- Morag Andrew (ORCID: https://orcid.org/0000-0003-2532-1655)
- Ioana R. Marian (ORCID: https://orcid.org/0000-0002-0692-8112)
- Catherine N. Barry
- Lesley Katchburian (ORCID: https://orcid.org/0000-0002-7523-7083)
- Beth Fordham (ORCID: https://orcid.org/0000-0001-5996-3563)
- Loretta S. Davis (ORCID: https://orcid.org/0000-0003-4417-3141)
- Joanna O'Mahoney
- Daniel C. Perry (ORCID: https://orcid.org/0000-0001-8420-8252)
- David J. Keene (ORCID: https://orcid.org/0000-0001-7249-6496)
- Ines Rombach (ORCID: https://orcid.org/0000-0003-3464-3867)
- Rachel Rapson (ORCID: https://orcid.org/0000-0001-8265-5358)
- Megan Stone
- H. Osborne
- Elnaz Saeedi
- Vivi Gregory Osborne
Institutions
- University of Liverpool (GB)
- Maidstone and Tunbridge Wells NHS Trust (GB)
- University of Exeter (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- University of Oxford (GB)
- Torbay and South Devon NHS Foundation Trust (GB)
- Newcastle University (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Bone & Joint Open
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1302/2633-1462.65.bjo-2024-0268
- Citations
- 2
- Primary Topic
- Cerebral Palsy and Movement Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Health Technology Assessment Programme