Population Pharmacokinetics of Rifampicin in Plasma and Cerebrospinal Fluid in Adults With Tuberculosis Meningitis
CSF penetration with standard-dose rifampicin is low. Our findings support continued evaluation of high-dose rifampicin for TBM treatment.
Authors
- Graeme Meintjes (ORCID: https://orcid.org/0000-0003-1196-4414)
- Robert John Wilkinson (ORCID: https://orcid.org/0000-0002-2753-1800)
- Cari Stek (ORCID: https://orcid.org/0000-0001-8813-0819)
- Noha Abdelgawad (ORCID: https://orcid.org/0000-0002-4907-345X)
- Lubbe Wiesner (ORCID: https://orcid.org/0000-0002-9070-8699)
- Paolo Denti (ORCID: https://orcid.org/0000-0001-7494-079X)
- Angharad Davis (ORCID: https://orcid.org/0000-0001-8914-5094)
- Kamunkhwala Gausi (ORCID: https://orcid.org/0000-0002-9002-8087)
- Sean Wasserman (ORCID: https://orcid.org/0000-0002-3508-6719)
Institutions
- University of Cape Town (ZA)
- St George's, University of London (GB)
- Queen Mary University of London (GB)
- The Francis Crick Institute (GB)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- Imperial College London (GB)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1093/infdis/jiaf178
- Citations
- 5
- Primary Topic
- Infectious Diseases and Tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust
- Francis Crick Institute
- UK Research and Innovation
- Cancer Research UK
- National Research Foundation
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- Eunice Kennedy Shriver National Institute of Child Health and Human Development