[Early life <i>Bifidobacterium bifidum</i> BD-1 intervention alleviates hyperactivity of juvenile female rats with attention deficit hyperactivity disorder].
Early life intervention with <i>B. bifidum</i> BD-1 alleviates hyperactivity in female SHRs by modulating the gut microbiota and peripheral immune response, suppressing neuroinflammation and improving dopaminergic system function. These findings provide evidence for early prevention strategies and support the development and application of psychobiotics for ADHD.
Authors
- Simou Wu (ORCID: https://orcid.org/0000-0002-5245-873X)
- J. Liu (ORCID: https://orcid.org/0009-0001-5695-5688)
- Ruyue Cheng (ORCID: https://orcid.org/0000-0001-9333-818X)
- Wen Jia (ORCID: https://orcid.org/0000-0001-7168-9392)
- Fang He (ORCID: https://orcid.org/0000-0001-7464-5272)
- Yang Yang (ORCID: https://orcid.org/0000-0003-0764-1575)
- Jinxing Li (ORCID: https://orcid.org/0000-0002-5888-342X)
- Kai Wang (ORCID: https://orcid.org/0000-0002-6151-0034)
- Zhimo Zhou
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-20
- DOI
- https://doi.org/10.12122/j.issn.1673-4254.2025.04.04
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article