Role of KLF5 in enhancing ovarian cancer stemness and PARPi resistance: mechanisms and therapeutic targeting
KLF5 enhances stemness and contributes to PARPi resistance in ovarian cancer through Vimentin regulation. Targeting KLF5 offers a promising therapeutic strategy to overcome resistance and improve patient outcomes.
Authors
- Huimin Xiao
- Guiyun Cheng
- Zhongshao Chen (ORCID: https://orcid.org/0000-0002-3083-7501)
- Yuehan Gao
- Shourong Wang (ORCID: https://orcid.org/0000-0003-3394-1299)
- Yao Liu (ORCID: https://orcid.org/0000-0002-7310-8800)
- Yanling Liu (ORCID: https://orcid.org/0000-0002-2027-6464)
- Feng Gao (ORCID: https://orcid.org/0000-0002-1000-385X)
- Haocheng Zhang (ORCID: https://orcid.org/0000-0002-2209-3629)
- Beihua Kong
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s12967-025-06502-6
- Citations
- 1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province