Bortezomib as a Potential Treatment for Recurrent Autoimmune Hepatitis Following Pediatric Liver Transplantation

This case emphasizes the effective use of bortezomib as a rescue therapy for steroid-resistant rejection and the recurrence of autoimmune hepatitis following pediatric liver transplantation. It highlights the significance of alternative therapeutic approaches in addressing complex post-transplant immune complications. Furthermore, this case prompts crucial considerations for future research, such as the monitoring of autoimmune disease reactivation and the potential role of drugs like bortezomib in managing immune-related complications after liver transplantation.

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Publication Details

Journal
Pediatric Transplantation
Published
2025-04-30
DOI
https://doi.org/10.1111/petr.70082
Citations
1
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
1.32
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article

Bortezomib as a Potential Treatment for Recurrent Autoimmune Hepatitis Following Pediatric Liver Transplantation

Konstantin Semash, P. M. Gadzhieva, A. R. Monakhov, Timur Dzhanbekov et al.
1 citations
Pediatric Transplantation
Liver Diseases and Immunity
1.32
article

Bortezomib as a Potential Treatment for Recurrent Autoimmune Hepatitis Following Pediatric Liver Transplantation

Konstantin Semash, P. M. Gadzhieva, A. R. Monakhov, Timur Dzhanbekov, Mansur Nasirov
article en
1 citations

Abstract

This case emphasizes the effective use of bortezomib as a rescue therapy for steroid-resistant rejection and the recurrence of autoimmune hepatitis following pediatric liver transplantation. It highlights the significance of alternative therapeutic approaches in addressing complex post-transplant immune complications. Furthermore, this case prompts crucial considerations for future research, such as the monitoring of autoimmune disease reactivation and the potential role of drugs like bortezomib in managing immune-related complications after liver transplantation.

Pediatric TransplantationVol. 29(4)
Sechenov University (RU), V.I.Shumakov Federal Research Center of Transplantology and Artificial Organs (RU), Tashkent Pediatric Medical Institute (UZ)
Good health and well-being
Openalex Percentile: Top 21%
Liver Diseases and Immunity
1.32
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