Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal
This work has laid a foundation for following efforts to make full sense of the biological mechanisms underlying the genetic adaptation.
Authors
- Wei Huang (ORCID: https://orcid.org/0000-0001-9561-5099)
- Lei Guo (ORCID: https://orcid.org/0000-0003-1733-1802)
- Tiesong Zhang
- Chenhui Zhang (ORCID: https://orcid.org/0000-0002-0124-6315)
- Weihua Shou
- Ying Wang
- Li Li (ORCID: https://orcid.org/0000-0001-6834-9274)
- Haifeng Wang (ORCID: https://orcid.org/0000-0001-7213-927X)
- Jinxiu Shi (ORCID: https://orcid.org/0009-0000-1123-8290)
Institutions
- Chinese National Human Genome Center (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s12864-025-11620-y
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai