An Atlas of Thyroid Hormone Responsive Genes in Adult Mouse Hypothalamus
We present an atlas of genes that respond to thyroid hormone in the adult mouse mediobasal hypothalamus. Based on droplet-based single nuclei RNA-seq method and batch transcriptome analyses, the atlas lists putative target genes of the hormone nuclear receptors in 20 different types of neuronal and glial cells. The transcriptional regulation of these genes varies extensively across neuronal and glial cell types. However, while astrocytes appear to be highly sensitive to thyroid hormone stimulation, differentiated oligodendrocytes are relatively insensitive. This atlas is expected to promote future investigations into the molecular and cellular mechanisms that underlie the numerous functions of thyroid hormone in the hypothalamic circuits.
Authors
- Julien Dellinger (ORCID: https://orcid.org/0009-0009-7807-9058)
- Karine Gauthier (ORCID: https://orcid.org/0000-0003-2961-6119)
- Suzy Markossian (ORCID: https://orcid.org/0000-0003-3545-569X)
- Denise Aubert (ORCID: https://orcid.org/0000-0002-1442-3384)
- Romain Guyot (ORCID: https://orcid.org/0000-0002-0029-6222)
- Shijia Wu (ORCID: https://orcid.org/0000-0002-0736-6641)
- Yves Dusabyinema
- Wenzheng Jiang (ORCID: https://orcid.org/0000-0003-4999-4168)
- Frédéric Flamant (ORCID: https://orcid.org/0000-0002-3360-2345)
- Sandrine Hughes (ORCID: https://orcid.org/0000-0003-3932-9180)
- Benjamin Gillet (ORCID: https://orcid.org/0000-0002-6610-4537)
- Marie Fackeure
Institutions
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut de Génomique Fonctionnelle de Lyon (FR)
- East China Normal University (CN)
Publication Details
- Journal
- Endocrinology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1210/endocr/bqaf084
- Citations
- 5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Equipex
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- China Scholarship Council
- Centre National de la Recherche Scientifique
- Université Claude Bernard Lyon 1
- École Normale Supérieure de Lyon