ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer’s disease
Combined, we provide new understanding to the sex differences in AD by demonstrating that ERβ protects against AD pathology differently in males and females, warranting reassessment of ERβ in combating AD.
Authors
- Mohamed M. Shamekh (ORCID: https://orcid.org/0000-0002-9345-1278)
- Per Nilsson (ORCID: https://orcid.org/0000-0001-6450-0870)
- Ivan Nalvarte (ORCID: https://orcid.org/0000-0001-6828-2583)
- Mukesh Varshney (ORCID: https://orcid.org/0000-0003-2165-0152)
- Silvia Maioli (ORCID: https://orcid.org/0000-0002-9577-0803)
- José Inzunza (ORCID: https://orcid.org/0000-0003-0876-6767)
- Heba Ali (ORCID: https://orcid.org/0000-0001-5535-7638)
- Aphrodite Demetriou (ORCID: https://orcid.org/0009-0000-3902-3881)
- Birgitta Lindqvist
Institutions
- Karolinska Institutet (SE)
- Assiut University (EG)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s13293-025-00711-w
- Citations
- 5
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.47
Funders
- American Breast Cancer Foundation
- Torsten Söderbergs Stiftelse
- Hjärnfonden
- Karolinska Institutet
- Vetenskapsrådet
- Bertil Hållstens Forskningsstiftelse
- RIKEN