Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA
In summary, Spike protein mutations in SARS-CoV-2 variants significantly influence immune responses by altering HLA-peptide interactions, with pronounced population-specific effects on HLA class II alleles. These findings underscore the critical role of HLA class II diversity in shaping immune responses and susceptibility to COVID-19. Integrating population-specific HLA profiles into vaccine development and public health strategies is essential for improving interventions against evolving SARS-CoV-2 variants.
Authors
- Chin‐Lin Guo (ORCID: https://orcid.org/0000-0002-8055-9482)
- Chang‐Jiun Wu (ORCID: https://orcid.org/0000-0001-8350-6397)
- M. Yu. Shkurnikov (ORCID: https://orcid.org/0000-0002-6668-5028)
- Wan‐Chen Huang (ORCID: https://orcid.org/0000-0002-7341-4373)
- Che‐Mai Chang (ORCID: https://orcid.org/0000-0002-0353-9744)
- Alexander Tonevitsky (ORCID: https://orcid.org/0000-0002-7079-7145)
- Wei‐Chiao Chang (ORCID: https://orcid.org/0000-0002-8573-5924)
Institutions
- National Research University Higher School of Economics (RU)
- Institute of Physics, Academia Sinica (TW)
- Institute of Cellular and Organismic Biology, Academia Sinica (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1186/s12929-025-01139-5
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Academia Sinica
- Ministry of Education
- Taipei Medical University
- National Taiwan University Hospital
- National Research University Higher School of Economics
- National Science and Technology Council