Longitudinal genomic profiling of chemotherapy-related CHIP variants in patients with ovarian cancer
Our innovative sequencing approach enabled the discovery of a large number of novel low-frequency candidate CHIP mutations, whose frequency and composition are affected by chemotherapy, in the cfDNA of patients with HGSC. The CHIP variants that were enriched after chemotherapy, if validated, might become essential predictive markers for therapy-related myeloid neoplasia.
Authors
- Amir A. Jazaeri (ORCID: https://orcid.org/0000-0003-4335-4151)
- Jun Yao (ORCID: https://orcid.org/0000-0003-1418-3576)
- Mohammad M. Mohammad
- Xingzhi Song (ORCID: https://orcid.org/0000-0002-9436-2728)
- Shannon N. Westin (ORCID: https://orcid.org/0000-0002-1922-0156)
- Sara Corvigno (ORCID: https://orcid.org/0000-0001-5458-2243)
- Richard A. Hajek (ORCID: https://orcid.org/0000-0001-6248-5283)
- Joseph Celestino (ORCID: https://orcid.org/0000-0002-7758-1558)
- Kenna Shaw (ORCID: https://orcid.org/0000-0002-6873-0793)
- Qingxiu Zhang (ORCID: https://orcid.org/0009-0001-0788-7228)
- Ency Arboleda Goette
- Ping Song (ORCID: https://orcid.org/0000-0002-7965-2399)
- Sanghoon Lee (ORCID: https://orcid.org/0000-0002-5086-1461)
- Jianhua Zhang (ORCID: https://orcid.org/0000-0002-3819-2437)
- Li Zhao (ORCID: https://orcid.org/0000-0002-1378-7434)
- Amma Asare
- Karen H. Lu
- Anil K. Sood
- Raymond N. Montoya
- Ridge T. Rogers
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Center for Personalized Cancer Treatment (NL)
- Institute of Predictive and Personalized Medicine of Cancer (ES)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fonc.2025.1538446
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00