Plasma microbial cell-free DNA characterization in different populations based on the droplet digital PCR method: a multi-cohort study
This study provides a comprehensive characterization of mcfDNA across different health states, demonstrating the utility of ddPCR in detecting microbial infections. These findings contribute to refining infection diagnostics and improving early detection strategies for BSIs and sepsis.
Authors
- Guanhua Wang (ORCID: https://orcid.org/0000-0001-9334-8740)
- Jingjia Zhang (ORCID: https://orcid.org/0000-0002-8285-950X)
- Jiang Xia
- Shuyi Yang (ORCID: https://orcid.org/0009-0004-1604-8874)
- Aiwu Ren
- Xiaogang Xiang (ORCID: https://orcid.org/0000-0003-0999-2950)
- Fengliu Wang
- Jingwen Ding
- Ye Zhao (ORCID: https://orcid.org/0000-0002-5455-2586)
- Xuesong Shang
- Dong Zhang (ORCID: https://orcid.org/0000-0003-0830-1310)
- Ying Liu (ORCID: https://orcid.org/0000-0001-9385-992X)
- Qiang Chen (ORCID: https://orcid.org/0000-0002-3559-1184)
- Yingchun Xu (ORCID: https://orcid.org/0000-0002-9457-5635)
- Jing Liu (ORCID: https://orcid.org/0000-0002-5281-9769)
- Li Peng (ORCID: https://orcid.org/0000-0001-5358-6736)
- Juan Du (ORCID: https://orcid.org/0000-0002-0051-6125)
- Qiwen Yang (ORCID: https://orcid.org/0009-0008-9652-6950)
- Shuang Jing
- Lu Bai (ORCID: https://orcid.org/0009-0002-9168-5465)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Annoroad Gene Technology (China) (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fmicb.2025.1578820
- Citations
- 2
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.43