Early reduction of skin potassium without sodium accumulation in the pathogenesis of salt sensitivity in primary aldosteronism
Aldosterone-treated rats on a high-salt diet for 2 days had lower skin and plasma potassium levels compared to salt-loaded controls, suggesting early potassium depletion precedes significant sodium accumulation and blood pressure increases. These findings raise the possibility that early potassium depletion contributes to the development of aldosterone-induced salt sensitivity. Further studies with detailed time-course analysis will be of interest to elucidate the role of early potassium depletion in increasing vascular resistance and triggering aldosterone-dependent salt sensitivity and hypertension.
Authors
- Michal Pravenec (ORCID: https://orcid.org/0000-0001-9197-5871)
- Miroslava Šimáková (ORCID: https://orcid.org/0000-0003-1468-5832)
- Jan Šilhavý (ORCID: https://orcid.org/0000-0001-8042-5890)
- František Liška (ORCID: https://orcid.org/0000-0002-9588-806X)
- Petr Mlejnek (ORCID: https://orcid.org/0000-0002-4218-8983)
- Theodore W. Kurtz (ORCID: https://orcid.org/0000-0003-0436-5456)
- Kateřina Večerková (ORCID: https://orcid.org/0009-0007-7387-8868)
Institutions
- University of California, San Francisco (US)
- Czech Academy of Sciences (CZ)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1575972
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy