Impact of CYP3A4 functional variability on ziprasidone metabolism
The findings of this study underscore the critical role of quercetin-mediated CYP3A4 inhibition and CYP3A4 genetic polymorphisms in modulating ziprasidone metabolism.
Authors
- Yameng Wu (ORCID: https://orcid.org/0000-0003-3267-3069)
- Zheyan Zhang (ORCID: https://orcid.org/0000-0002-8339-2606)
- Kai Zheng (ORCID: https://orcid.org/0000-0001-6591-7264)
- Zhize Ye
- Lu Yang (ORCID: https://orcid.org/0009-0008-0443-382X)
- Zhongxiang Xiao
- Jianchang Qian
- Qi Zhou (ORCID: https://orcid.org/0000-0001-6716-9263)
Institutions
- Wenzhou Medical University (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1585040
- Citations
- 2
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.11