Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway
These findings demonstrate that Op D can improve β-cell dedifferentiation by modulating the GRP78/ROS/PDX1 pathway to inhibit ER stress.
Authors
- Jiuyao Zhou (ORCID: https://orcid.org/0000-0003-3477-3370)
- Jianping Song (ORCID: https://orcid.org/0000-0002-3839-8769)
- Changsheng Deng (ORCID: https://orcid.org/0000-0003-3815-3566)
- Ruixiang Tan
- Ying Xie (ORCID: https://orcid.org/0000-0002-9535-8958)
- Cheng Zhang (ORCID: https://orcid.org/0000-0001-8932-0585)
- Yimeng Li (ORCID: https://orcid.org/0009-0005-7357-8473)
- Yongzhi Sun
- Haoxiang Sun (ORCID: https://orcid.org/0000-0003-0281-1555)
- Manxue Mei (ORCID: https://orcid.org/0009-0003-5958-3204)
- Wei Zhu (ORCID: https://orcid.org/0009-0006-2060-521X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1563201
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- National Natural Science Foundation of China