Protective effect of brain microvascular endothelial cell-derived exosomes on blood-brain barrier induced by ischemia-reperfusion injury in vivo and in vitro
In conclusion, EC-Exo enhances BBB integrity by activating PDGF-PDGFRβ and Ang1/Ang2-Tie2 signaling pathways, promoting communication between endothelial cells and pericytes. This introduces an innovative adjuvant therapy for treating ischemic stroke.
Authors
- Qing Yuan (ORCID: https://orcid.org/0000-0003-4058-5931)
- Shaoxia Wang (ORCID: https://orcid.org/0000-0002-1762-8684)
- Limin Hu (ORCID: https://orcid.org/0000-0002-3852-5756)
- Lichen Guo
- Yushuang Cao
- Linlin Su (ORCID: https://orcid.org/0000-0002-9381-1114)
- Jin Sun (ORCID: https://orcid.org/0000-0002-1238-6399)
- M. Wang (ORCID: https://orcid.org/0000-0002-4713-9646)
- Lijuan Chai (ORCID: https://orcid.org/0000-0002-6719-5442)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fphar.2025.1548122
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61