Comparison of the effects of metformin and empagliflozin on cardiac function in heart failure with preserved ejection fraction mice
MET and EMPA improve cardiac fibrosis, diastolic function, and pulmonary congestion in HFpEF mice. MET acts by downregulating TGFβ, while EMPA affects collagen metabolism and downregulates HSP90 and TGFβ. These findings offer insights into HFpEF treatment.
Authors
- Zhaofen Zheng
- Xiehong Liu (ORCID: https://orcid.org/0000-0002-1059-790X)
- Huiqi Zhao (ORCID: https://orcid.org/0000-0002-0856-560X)
- Wenjuan Fan (ORCID: https://orcid.org/0000-0001-8620-3383)
- Hongwei Pan (ORCID: https://orcid.org/0000-0002-4287-481X)
- Qinghai Zhang (ORCID: https://orcid.org/0000-0002-5272-6159)
- Sisi Liu
- Bo Cui (ORCID: https://orcid.org/0000-0001-6869-2523)
- Jianqiang Peng
- Qiong Xie (ORCID: https://orcid.org/0000-0002-8317-1774)
- Siao Wen (ORCID: https://orcid.org/0009-0002-1314-8752)
- Lin Zhou (ORCID: https://orcid.org/0000-0003-1674-9692)
Institutions
- Changsha Medical University (CN)
- Hunan Normal University (CN)
- Hunan Provincial People's Hospital (CN)
- Education Department of Hunan Province (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fcvm.2025.1533820
- Citations
- 7
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 9.06