Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure
Even at subtherapeutic levels, cisplatin disrupts NSPC integrity, driving differentiation through mitochondrial ROS-dependent mechanisms. While inhibiting ROS reduced differentiation, it did not restore NSPC proliferation. These findings highlight the vulnerability of NSPCs to cisplatin, even at doses considered safe. The metabolic shift toward mitochondrial respiration may contribute to this differentiation bias. Future research on co-administration of antioxidant agents during chemotherapy could protect NSPC integrity and mitigate developmental and cognitive risks, especially in neonates exposed via breastfeeding.
Authors
- Claudia Altamirano (ORCID: https://orcid.org/0000-0002-6389-086X)
- Felipe A. Bustamante-Barrientos
- María Jesús Araya (ORCID: https://orcid.org/0000-0003-1641-9167)
- Noymar Luque‐Campos
- Eduardo Silva-Pavez (ORCID: https://orcid.org/0000-0002-9650-7521)
- Ana María Vega-Letter (ORCID: https://orcid.org/0000-0001-9259-8174)
- Eliana Lara-Barba (ORCID: https://orcid.org/0000-0001-5148-9959)
- Patricia Luz‐Crawford (ORCID: https://orcid.org/0000-0003-0067-7743)
- Yeimi Herrera-Luna (ORCID: https://orcid.org/0000-0002-4301-6083)
- Liliana Yantén-Fuentes
- Jonathan Morales-Reyes
- Cynthia García-Guerrero
Institutions
- Pontificia Universidad Católica de Valparaíso (CL)
- Universidad de Los Andes, Chile (CL)
- San Sebastián University (CL)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fcell.2025.1555153
- Citations
- 6
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 7.91
Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico