Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation
This study is the first to demonstrate that BIC specifically alleviates lipid accumulation and hepatic steatosis in MASLD models <i>via</i> the NF-κB signaling pathway. Overall, BIC has emerged as a promising candidate for treating MASLD.
Authors
- Yuping Zhou (ORCID: https://orcid.org/0000-0003-0693-4747)
- Ze Dai
- Naibin Yang
- Daru Lu (ORCID: https://orcid.org/0000-0001-6748-7966)
- Xiaomei Wang (ORCID: https://orcid.org/0000-0002-1927-6336)
- C. Bao
Institutions
- Ningbo University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3748/wjg.v31.i17.105438
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00