Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation
These findings suggest that dysregulated calcium signaling in ERC, beginning in middle-age, may prime tau for hyperphosphorylation, potentially driving the early stages of AD, advancing our understanding of how ERC vulnerabilities contribute to neurodegeneration in AD.
Authors
- Amy F.T. Arnsten (ORCID: https://orcid.org/0000-0002-3420-1308)
- Angus C. Nairn (ORCID: https://orcid.org/0000-0002-7075-0195)
- Shveta Bathla
- Elizabeth Woo (ORCID: https://orcid.org/0000-0002-7060-7575)
- Dibyadeep Datta (ORCID: https://orcid.org/0000-0002-5415-3067)
- Jon I. Arellano (ORCID: https://orcid.org/0000-0002-9840-5756)
- Alvaro Duque (ORCID: https://orcid.org/0000-0002-5086-5438)
- Dinara Bolat
Institutions
- Yale University (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fnagi.2025.1549770
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Alzheimer's Association
- Yale University
- National Institutes of Health