Safety and necessity of omitting mediastinal lymph node dissection in cN0/N1 non-small cell lung cancer after neoadjuvant immunotherapy
Omitting systemic mLN dissection was safe in cN0/N1 NSCLC patients who received neoadjuvant immunotherapy. Excessive mLN dissection may disrupt the repertoire of stem-like exhausted CD8<sup>+</sup> memory T cells and consequently impair the efficacy of adjuvant immunotherapy.
Authors
- Wenyu Zhai
- Yan Zheng (ORCID: https://orcid.org/0000-0003-1788-9179)
- Yuheng Zhou
- Hailin Tang (ORCID: https://orcid.org/0000-0002-3206-782X)
- Di‐Han Liu
- Yaobin Lin (ORCID: https://orcid.org/0000-0002-6716-0530)
- Hao Long (ORCID: https://orcid.org/0000-0001-5623-9799)
- Zhichao Lin (ORCID: https://orcid.org/0000-0001-7083-1449)
- Weizhen Sun
- Xiaojuan Luo
- Han Yong-ping
- Shoucheng Feng
- Ze-Rui Zhao (ORCID: https://orcid.org/0000-0001-8829-7248)
Institutions
- Sun Yat-sen University (CN)
- Hunan City University (CN)
- Henan Cancer Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Jiangmen Central Hospital (CN)
- Yantai Laiyang Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1587658
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China
- National Health Commission of the People's Republic of China